BITS HD (BITS HIGHER DEGREE) EXAMINATION
Details of the Online Test
The test will be a computer based online test conducted by BITS Pilani at dedicated Centers in different cities of India. Computer based online test means the candidate sits in front of a computer and the questions are presented on the computer monitor and the candidate submits the answers through the use of keyboard & mouse. Each computer is connected to a server, which prepares the question set and delivers to the candidate on the computer.
Test I: Duration: 45 Minutes. Total No of questions: 30
Mathematics -15 Marks
English Language Skills & Logical Reasoning-15 Marks
Test II: Duration: 105 Minutes. Total number of questions: 70
SYLLABUS FOR TEST-I Duration: 45 Minutes. Total No of questi
Core Mathematics
Duration: 45 Minutes. Total No of questions: 30
Mathematics -15 Marks
English Language Skills & Logical Reasoning-15 Marks
Calculus: Functions and graphs; limit and continuity; Applications of Derivatives, Applications of Definite Integrals, Convergence of Infinite sequences and series, Maclaurin and Taylor series. Functions of several variables, Limits and Continuity in Higher Dimensions, Partial derivatives, The chain rule, Directional Derivatives and Gradient vectors, Tangent planes and Normal lines, Extreme values and saddle points, Double Integrals, Triple Integrals, Line and surface Integrals, Conservative fields, Curl and divergence, Theorems of Green, Gauss and Stokes.
Linear Algebra: Matrix Algebra, Row reduction method, Rank and inverse of a matrix, System of linear equations, Vector space; basis and dimension; linear transformation; range and kernel of a linear transformation; Eigenvalues and eigenvectors.
Complex Variables: Analytic functions, Cauchy’s theorems; Cauchy’s integral formula, Taylor Series and Laurent Series; Calculus of residues and applications.
Probability and Statistics: Sample space and events, Conditional probability and independence; Random variables and probability distributions; Independent random variables; Mathematical expectation; mean and variance; Geometric, Binomial, Poisson’s, Exponential, Gamma and Normal distributions; sum of independent random variables; law of large numbers; Central limit theorem, Marginal and conditional distributions; Sampling distribution, Point estimation, Statistical intervals based on a Single sample, Tests of hypotheses based on a single sample, test for mean using normal and Students t-distribution; Correlation and linear regression.
Differential Equations: First order differential equations (linear and nonlinear), higher order linear differential equations with constant coefficient, method of variation of parameters, Cauchy-Euler’s equation, Fourier Series, Laplace Transform, Initial and boundary value problems, Partial differential equations, Method of separation of variables.
Numerical Methods: Solution of nonlinear algebraic equations: Newton’s method, Secant method, fixed point iteration method, method of false position, Solution of system of linear equations: Direct methods & Iterative methods, LU decomposition, Integration by Trapezoidal and Simpson’s rule.
English Language and Logical Reasoning
(a) English Language This test is designed to assess the test takers’ general proficiency in the use of English language as a means of self-expression in real life situations and specifically to test the test takers’ knowledge of basic grammar, their vocabulary, their ability to read fast and comprehend, and also their ability to apply the elements of effective writing.
1. Grammar
1.1 Agreement, Time and Tense, Parallel construction, Relative pronouns
1.2 Determiners, Prepositions, Modals, Adjectives
1.3 Voice, Transformation 1.4 Question tags, Phrasal verbs
2. Vocabulary
2.1 Synonyms, Antonyms, Odd Word, One Word, Jumbled letters, Homophones, Spelling
2.2 Contextual meaning
2.3 Analogy
3. Reading Comprehension
3.1 Content/ideas
3.2 Vocabulary
3.3 Referents
3.4 Idioms/Phrases
3.5 Reconstruction (rewording)
4. Composition
4.1 Rearrangement
4.2 Paragraph Unity
4.3 Linkers/Connectives
(b) Logical Reasoning
The test is given to the candidates to judge their power of reasoning spread in verbal and nonverbal areas. The candidates should be able to think logically so that they perceive the data accurately, understand the relationships correctly, figure out the missing numbers or words, and to apply rules to new and different contexts. These indicators are measured through performance on such tasks as detecting missing links, following directions, classifying words, establishing sequences, and completing analogies.
5. Verbal Reasoning
5.1 Analogy: Analogy means correspondence. In the questions based on analogy, a particular relationship is given and another similar relationship has to be identified from the alternatives provided.
5.2 Classification: Classification means to assort the items of a given group on the basis of certain common quality they possess and then spot the odd option out.
5.3 Series Completion Here series of numbers or letters are given and one is asked to either complete the series or find out the wrong part in the series.
5.4 Logical Deduction: Reading Passage Here a brief passage is given and based on the passage the candidate is required to identify the correct or incorrect logical conclusions.
5.5 Chart Logic here a chart or a table is given that is partially filled in and asks to complete it in accordance with the information given either in the chart / table or in the question.
6. Nonverbal Reasoning
6.1 Pattern Perception: Here a certain pattern is given and generally a quarter is left blank. The candidate is required to identify the correct quarter from the given four alternatives.
6.2 Figure Formation and Analysis: The candidate is required to analyze and form a figure from various given parts.
6.3 Paper Cutting: It involves the analysis of a pattern that is formed when a folded piece of paper is cut into a definite design.
6.4 Figure Matrix: In this more than one set of figures is given in the form of a matrix, all of them following the same rule. The candidate is required to follow the rule and identify the missing figure.
6.5 Rule Detection: Here a particular rule is given and it is required to select from the given sets of figures, a set of figures, which obeys the rule and forms the correct series.
SYLLABUS FOR TEST-II
Pharmacy Natural Drugs, Phyto chemistry, Pharmacognosy
Duration: 105 Minutes.
Total number of questions: 70
General Pharmacognosy, traditional systems of medicine, plant nomenclature & classification, macro & micro morphology, standardization parameters;
Properties, isolation techniques, tests and functions of alkaloids, alkaloidal drugs belonging to the classes: tropane, ecgonine, quinoline, iso-quinoline, indole, purine, phenanthrine, diterpene, peptide, steroidal classes including pseudoalkaloids;
Classification, isolation techniques, test for glycosides, glycoside drugs of class: anthraquinone, cardenolide, bufedienolide, saponins; Classification, isolation techniques, tests for volatile oils and fixed oils, volatile oil containing drugs including acyclic, monocyclic, bicyclic and tri cyclic terpenoidal drugs, fixed oils containing saturated, unsaturated fatty acids; Classification, isolation procedures, test for resins, drugs of resin alcohol, acid resin and ester resin classes, classification and tests for gums, prepared gums and naturally occurring gums.
Reference books: Trease & Evans ‘Pharmacognosy’ Saunders, 15th Ed., 2002.Wallis T. E. ‘Text book of Pharmacognosy’, 5th Ed. 1997xee.
Anatomy Physiology & Hygiene:
Anatomy of a generalized cell, cellular transport mechanisms, cell division, body tissue types and functions, their properties and characteristics., Composition and functions of blood, Plasma Proteins, RBC, WBC, platelets- anatomy & functions, hemoglobin and blood groups, blood typing, anatomy and physiology of the heart, blood pressure, ECG and its significance, blood vessels., General aspects of neurology, central, peripheral nervous system ( CNS and PNS), autonomic nervous system, endocrine glands, hormones:- their functions and mechanisms of action., Anatomy of the urinary system, mechanisms of urine production, diseases of the kidney, male, female reproductive systems and related disorders., Organs of the respiratory system, process of respiration, diseases related to the systems.
Reference books: Martini F H – Fundamentals of Human Anatomy & Physiology. 4 th Ed, P-H International Inc. Guyton & Hall,
A Text book of Medical Physiology XI Ed., WB Saunders Co.(Indian Ed.), Elsevier 2006
Pharmaceutical Chemistry (Medicinal Chemistry, Chemistry of Synthetic Drugs and Applied Pharmaceutical Chemistry)
Physico-chemical and stereo chemical properties affecting drug actions, drug-receptor interactions, prodrugs and drugs metabolism., Classification, structure, synthesis, S.A.R. and mechanism of action of local anaesthetics, sedatives, hypnotics, anti-histaminics, antihypertensive agents., Various organic reactions involved in drug synthesis, addition, condensation, rearrangement, carbon – carbon bond formation, carbon- heteroatom bond formation, heterocyclic ring forming reactions., Chemotherapeutic agents: sources, synthesis and S.A.R, mechanisms of action of anti-bacterial, anti-cancer, anti-viral agents., Lead compound identification, retero-synthetic analysis, bio-technological approach to drug design and development, alkyl chain addition / deletion, ring expansion, ring contraction methods, synthesis and use of intermediates in organic systems.
Reference books:
Foye, William. “Principles of Medicinal Chemistry’ – Lippincott Williams & Williams, 5 th Ed., 2002.
D. Sriram, P-Yogeeswari “Medicinal Chemistry” Pearson Education, I Ed., 2007.
Pharmaceutical and Instrumental Methods of Analysis:
IR, NMR, MASS – spectroscopic techniques, their principles, instrumentation, molecular characterization, calibration, operation, sample preparation and interpretation of results., UV-Vis. Spectrophotometer, spectrofluorimeter, AAS: - their principles, instrumentation, calibration, operation, sample preparation and interpretation of results., Chromatographic Techniques – HPLC, GC, Paper, Gel electrophoresis – their principles, instrumentation, calibration, operation, sample preparation and interpretation of results., Titrimetric methods – neutralization (aqueous and non-aqueous), redox, precipitation, complexometric, iodometric and iodimetric titrations: – their principles, applications, assay techniques., Limit tests, microbiological assay, determination of water content, methoxyl groups; T.L.C, paper and column chromatographic techniques and their applications.
Reference books:
Willard H. H. “Instrumental Methods of Analysis” CBS, 7th Ed. 1988.
Beckett and Stenlake J.B. ‘Practical Pharmaceutical Chemistry’ – 4 th Ed. Part I & II, 1997.
Pharmacology and Toxicology:
Introduction, Scope and principles of basic pharmacology and toxicology, mechanisms of drug action, receptors and drug action, pharmacodynamic parameters affecting drug- receptor interaction, Pharmacokinetics and Pharmacodynamics., Cholinergic drugs, cholinergic blockers, adrenergic drugs and their blockers, ganglionic and neuromuscular blocking agents – their mechanisms action., General and local anesthetics, anxiolytics, sedatives and hypnotics, antipsychotics and antidepressants, narcotic and non-narcotic drugs, NSAID’s, CNS stimulants anti-convulsants, anti-parkinsonics agents, their mechanisms., Cardiotonics, antianginals, antihypertensives, diuretics, anti-arrhythmic, drugs for blood disorders – their mechanisms., Principles of Chemotherapy, classification of chemotherapeutic agents, folate antagonists, protein, cell wall synthesis inhibitiors, quinolone antibiotics, drugs for UTI, antifungal, antiviral, antitubercular, anthelmintics, antimoebics, anti-cancer drugs.
Reference books: Goodman & Gilman’s “The Pharmacological Basis of Therapeutics’ - Fundamentals, 10th Ed., McGraw Hill, 2001.
M J Mycek et.al. Lippincott’s Illustrated reviews – Pharmacology-Lippincott-Ramen-III Ed. 2001.
Pharmaceutical Microbiology and Biochemistry:
Introduction and classification of microbes, bacteria, virus, fungi, protozoa – physiology and cellular function, infections and immunity, microbials in antibiotic and vaccine preparations., Nutritional requirements and cultivation of microbes, culture media types, physical and chemical methods of microbial control, staining techniques, sterility testing and their validation, sterilization methods and applications., Microbial mechanisms of human pathogenicity, diseases of the skin, CNS, GIT, Respiratory Tract, immune system disorders, antimicrobial drugs and their evaluation., Carbohydrates Lipids, Proteins, Nucleic acids: their structures, biosynthesis, biochemical energetic functions, clinical pathology, deficiency disorders., Enzymes and their regulation; classification, structures, kinetics, inhibition mechanisms, applications.
Reference books:
Microbiology – An introduction – 8 th Ed. Tortora, et.al Pearson Pub., 2004.
Prescott et.al Microbiology’ 6th Ed. McGraw Hill, 2005.
“Lehninger Principles of Biochemistry” – David L Nelson W.H, Framan & Co, 4 th Ed. 2004.
Forensic Pharmacy and Quality Control Management:
Regulatory control of manufacturing and sales of pharmaceuticals and cosmetics, Drugs & Cosmetics Act, Medicinal and Toilet Preparations Act, Narcotics and Psychotropic Substances Act., Regulatory control of teaching and practice of Pharmacy: Pharmacy Act, Objectionable Advertisements Act, Shops and Establishments Act, Drug Price Control Order, Quality Assurance and Quality Audit: QC/QA functions, GLP, Quality audit, ISO certification, Good Manufacturing Practices: All aspects of good manufacturing practices, documentation, protocols involved, design of premises., Pharmaceutical Management: Planning, organizing, controlling of pharmaceutical manufacturing and marketing activities.
Reference books:
B.M. Mittal – Textbook of Forensic Pharmacy Vallabh Prakashan, 10 th Ed., 1999. Khanna O.P., Industrial Engineering and Management, Dhanpat Rai Rev. Ed. 1999. Willing, et.al, Good Manufacturing Practice for Pharmacy: A plan for Total Q.C, Marcel Dekker, 5 th Ed., 2001.
Industrial And Physical Pharmacy:
Physicochemical properties of Pharmaceutical agents, Rheology, Interfacial phenomenon, Micromeretics, Raw materials and Materials of construction of equipments., Kinetic Phenomenon, Chemical Kinetics, Stability testing, Dissolution, Diffusion., Materials of construction, Extraction, Communition, Mixing., Heat transfer, Distillation, Evaporation, Drying, Fluid Flow, Humidification, Dehumidification., Filtration, Crystallization, Compression.
Reference books: Aulton M.E – ‘Pharmaceutics -The Science of Dosage Form Design-Churchill Livingston, 2nd Ed. 2002 or ELBS,
Ed. Lachmann, L. and Others – Theory and Practice of Industrial Pharmacy Lea Feberger 3 rd ed. 1986.
Pharmaceutical Formulations and Biopharmaceutics:
Pre-formulation studies, Physicochemical properties of drugs and their impact on design of drug delivery systems, classification of dosage forms; Design, Preparation, Evaluation of Pharmaceutical Dosage Forms: Tablets, Solutions, Capsules ,Micro-encapsulation techniques;, Design, Preparation and Evaluation of Novel Drug Delivery Systems such as : Sustained Release, Controlled Release, Transdermal and Transmucosal, Ocular., Parenteral Products: Sterilization methodology, calculations, evaluation and preparation., Biopharmaceutics: ADME characteristics of drug and their importance in 29 disease conditions, Pharmacokinetic drug interactions, bio-equivalence and bio-availability studies, Prodrugs.
Reference books: Mittal B.M., - Text book of Pharmaceutical Formulation – Vallabh Prakashan 6th Ed. 1997.
Brahmanker et al – Biopharmaceutics and Pharmacokinetics - A Treatise, Vallabh Prakashan, 1995.
Dispensing Pharmacy:
General Dispensing Procedures, Latin terms and Abbreviations, Pharmaceutical Calculations, Posology., Disperse Systems: Suspensions, Emulsions, Creams: General methods of manufacturing, problems associated with stability., Semi-solid Preparations like Ointments, Gels, Pastes, Suppositories and Pessaries: General methods of manufacturing, problems associated with stability., Incompatibilities involved in prescriptions and usage of additives., Containers and Closures: selection of appropriate containers and closures, Hospital Pharmacy Practice.
Reference books:
Cooper and Gunn – Dispensing for Pharmaceutical students – CBS, 12th ed., 1987
